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Silkworms are susceptible to a range of pathogenic diseases, which are primarily caused by protozoan, fungal, bacterial and viral agents. These infections can significantly impact the health and productivity of the silkworm population, thereby affecting silk cocoon quality and yield. Prevention of these diseases is very important to get stable cocoon crops. Many general disinfectants are used to disinfect the silkworm rearing house at famers as a precautionary measure. In the present study, assessment of widely accepted Astra, Sanitech, Bleaching powder and Formalin general disinfectants was conducted against mulberry silkworm diseases and its impact on FC1×FC2 bivoltine double hybrid rearing at farmer’s field level. The results revealed that, Bleaching powder solution sprayed rearing house batch has shown best results in minimum larval duration (22.06 days), 10 matured larval weight (45.3 g), highest shell ratio (22.62%), highest yield/ 100 DFLs (78 kg) and rate kg-1 cocoons (Rs. 513.00). Astra, Sanitech and Formalin sprayed silkworm rearing baches occupies second, third and fourth places, respectively. The clean water sprayed rearing batches have shown very poor cocoon qualitative and quantitative parameters. The bleaching power sprayed could able to suppress diseases intensity and maintained healthy environment because of which the silkworms were healthy. Based on the perusal of the results obtained, bleaching powder is suggested for the disinfection of the rearing houses.

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